Endocrine Abstracts

Introduction: Subclinical hyperthyroidism (SH) is defined by normal thyroid hormone levels and reduced thyroid-stimulating hormone (TSH) concentration. It still raises intriguing questions about its clinical impact, management and outcomes. The aim of our study was to determine the underlying etiologies of SH, its clinical features and its outcomes in Tunisian patients.Methods: We conducted a retrospective study at Charles Nicolle Hospital, including 46 ...

Introduction: Homeostasis of calcium and phosphor influence bone metabolism. They depend on several hormones, including parathyroid hormone, thyroid and sexual hormones. Low bone mass seems a common issue in endocrine disorders. The aim of this study is to identify the different endocrine disorders in patients with low bone mass.Methods: Retrospective study collecting the medical files of patients followed in the endocrinology department of Charles Nicol...

Introduction: Diabetes is a chronic, progressive disease characterized by elevated levels of blood glucose. In type 1 diabetes, some patients experience a “honeymoon period” shortly after diagnosis, wherein insulin needs decrease significantly and a few studies have demonstrated that drug-free glycemic control can be achieved in type 2 diabetes. We describe 2 unusual cases of endogenous hyperinsulinism and diabetes remission.Case presentation 1...

Introduction: Multiple endocrine neoplasia (MEN1) is a rare underdiagnosed inherited multi-tumor syndrome, affecting neuroendocrine and non-endocrine tissues. Its aspects are extremely variable with no genotype-phenotype correlation.Case report: A 57 year old woman with a history of hypertension, presented five months before her admission with asthenia, headache and vomiting, initial biological exams revealed a central hypothyroidism. A pituitary MRI sho...

Introduction: Since the hypothalamic-puituitary axis (HPA) is a radiosensitive region, cranial radiotherapy for head and neck malignancies represents a major risk factor for the development of endocrine complications particularly hypopituitarism.Case report: A 22 years old girl with a history of a undifferentiated carcinoma of nasopharyngeal type UCNT at the age of 09 years old treated with radiotherapy and chemotherapy was referred to the endocrinology ...

Introduction: Graves disease is a frequent etiology of hyperthyroidism. It is defined as a diffuse hyperfunctioning of the thyroid gland caused by an autoimmune disorder. We herein present a rare case of unilateral Graves disease involving the right lobe of the thyroid.Observation: A 44-year-old woman was referred for investigation of subclinical hyperthyroidism revealed by a routine check-up. On physical examination, she had tremor, eyelid retraction, t...

Introduction: Thyrotoxicosis is an uncommon cause of cholestasis. It’s a diagnostic challenge considering the broad differential diagnosis. Herein we report a case of Grave’s disease revealed by severe cholestatic jaundice.Observation: A 46 old male with a history of Sickle cell disease complained of diarrhea and significant weight loss for eight months, followed the last month by palpitations, heat intolerance, anxiety, insomnia and progressiv...

Introduction: Pheochromocytomas are rare catecholamine-secreting tumors presenting with various clinical manifestations. Hypertension is the most common finding in pheochromocytomas. It can be either persistent or paroxysmal. Study Design: We conducted a retrospective study of 34 patients who were admitted into the endocrinology department of Charles Nicolle hospital, with a diagnosis of a pheochromocytoma from January 2005 to November 2022.Results: Twen...

Introduction: Pheochromocytomas are rare, mostly benign catecholamine-producing neuroendocrine tumors. Clinical manifestations are heterogenous, including persistent or paroxysmal hypertension, sweating, palpitation and headaches known as Menard triad. Diagnostic approach is based on demonstration of catecholamine excess and tumor localization. Our study aimed to describe clinico-biological and radiological features of pheochromocytomas.Methods: We condu...

Introduction: Excessive production of growth hormone (GH) in acromegaly is most commonly caused by a somatotroph pituitary adenoma. The therapeutic arsenal is based on selective transsphenoidal adenomectomy (STA) as a first-line treatment. The aim of our study was to determine predictive factors of postoperative biochemical remission in acromegalic patients.Methods: We conducted a retrospective study including 18 acromegalic patients followed-up in the e...